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Stem Cells Regrow Damaged Heart Muscle
Topic Started: Feb 14 2012, 03:28 PM (233 Views)
George K
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Finally
Faster, please....

http://www.cbsnews.com/8301-504763_162-57377323-10391704/stem-cells-heal-heart-attack-scars-regrow-healthy-muscle/

A new study offers an effective way to mend a broken heart: Stem cells.

The study looked at patients with damaged hearts from myocardial infarctions, or heart attacks, and found stem cells reduced the amount of scarring and helped hearts regrow healthy muscle.

"This discovery challenges the conventional wisdom that, once established, scar is permanent and that, once lost, healthy heart muscle cannot be restored," study co-author Dr. Eduardo Marban, director of the Cedars-Sinai Heart Institute and inventor of the techniques used in the procedure, said in a hospital written statement.

For the study, researchers tested 25 patients, an average of 53 years old, who had experienced heart attacks that had left them with damaged heart muscle. Eight patients served as controls and were treated with conventional treatments including medication, and diet and exercise recommendations. The other 17 patients received stem cells, which researchers derived from raisin-sized pieces of patients' own heart tissue.

The researchers found that patients treated with stem cells experienced almost a 50 percent reduction of heart attack scars within 12 months of treatment, while the eight patients who received conventional treatment saw no reductions in damage.

"This has never been accomplished before, despite a decade of cell therapy trials for patients with heart attacks. Now we have done it," Marban said. "The effects are substantial, and surprisingly larger in humans than they were in animal tests."

The study is published online in the Feb 13. Issue of The Lancet.

One of the 17 patients in the study, 59-year-old Fred Lesikar of Menifee, Calif., said his major heart attack reduced his heart function by more than 30 percent.

"The doctors treating me told me that there was no way to repair a heart damaged by a heart attack," he told Cedars-Sinai. But then he saw a news report on the study and called Cedars-Sinai, asking to be a part of the trial. "Today I'm feeling super - better than I did before the heart attack."

Dr. Sonia Skarlatos, deputy director of the division of cardiovascular sciences at the NIH's National Heart, Lung, and Blood Institute, told CNN that the procedure needs to be tested on more patients before it rolls out to the public, but remains hopeful it can improve quality of life for heart attack patients.

She said, "By preventing the consequences of a heart attack you may be able to prevent further down the heart failure that happens in [many of these] patients."
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KlavierBauer
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HOLY CARP!!!
Yes - faster please.
"I realize you want him to touch you all over and give you babies, but his handling of the PR side really did screw the pooch." - Ivory Thumper
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George K
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Finally
This is a VERY big deal. As you probably know, KB, therapy for heart disease is usually not therapy for the heart, per se, but directed at ways of reducing the workload of the heart, so that what muscle remains is more efficient. This actually grows new muscle.

Exciting.

A TV story I saw about this said that it's possible that we could be seeing this as a therapeutic modality within 5 years.
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"Now look here, you Baltic gas passer... "
- Mik, 6/14/08


Nothing is as effective as homeopathy.

I'd rather listen to an hour of Abba than an hour of The Beatles.
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KlavierBauer
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HOLY CARP!!!
Its very exciting, as I'm still constantly on the precipice of being called in at any time for another valve replacement.

If we can strengthen heart muscle, and potentially fix damaged valve tissue, I would be thrilled.
"I realize you want him to touch you all over and give you babies, but his handling of the PR side really did screw the pooch." - Ivory Thumper
"He said sleepily: "Don't worry mom, my dick is like hot logs in the morning." - Apple

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Mikhailoh
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If you want trouble, find yourself a redhead
That is awesome, incredible news. Does it have any other anticipated applications?
Once in his life, every man is entitled to fall madly in love with a gorgeous redhead - Lucille Ball
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brenda
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..............
Holy cow! This is big news indeed. This is a real leap in medical news.
“Weeds are flowers, too, once you get to know them.”
~A.A. Milne
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jon-nyc
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Cheers
Faster, indeed. Then lets regrow lung tissue the same way.
In my defense, I was left unsupervised.
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brenda
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..............
jon-nyc
Feb 14 2012, 05:43 PM
Faster, indeed. Then lets regrow lung tissue the same way.
:hug: Yes.
“Weeds are flowers, too, once you get to know them.”
~A.A. Milne
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kenny
HOLY CARP!!!
But doesn't the Pope say using embryonic stem cells is sinful, or something yucky-poo?

Or are these stem cells not embryonic or something?

. . . so hard to keep this all straight. :doh:
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George K
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Finally
kenny
Feb 14 2012, 06:01 PM
But doesn't the Pope say using embryonic stem cells is sinful, or something yucky-poo?

Or are these stem cells not embryonic or something?

. . . so hard to keep this all straight. :doh:
These are the patient's own stem cells.

Even the eveeeeellll BOOOSH allowed Federal funding for embryonic stem cell research, as long as the research used existing cell lines.
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"Now look here, you Baltic gas passer... "
- Mik, 6/14/08


Nothing is as effective as homeopathy.

I'd rather listen to an hour of Abba than an hour of The Beatles.
- Klaus, 4/29/18
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kenny
HOLY CARP!!!
George, thanks for setting me straight.
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Improviso
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HOLY CARP!!!
George K
Feb 14 2012, 06:07 PM
Even the eveeeeellll BOOOSH allowed...
Posted Image I LOVE bush. Oh, oh...you mean the president.
Identifying narcissists isn't difficult. Just look for the person who is constantly fishing for compliments
and admiration while breaking down over even the slightest bit of criticism.

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George K
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Finally
kenny
Feb 14 2012, 06:08 PM
George, thanks for setting me straight.
Not a chance in hell of that ever happening.
Edited by George K, Feb 14 2012, 06:11 PM.
A guide to GKSR: Click

"Now look here, you Baltic gas passer... "
- Mik, 6/14/08


Nothing is as effective as homeopathy.

I'd rather listen to an hour of Abba than an hour of The Beatles.
- Klaus, 4/29/18
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Improviso
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HOLY CARP!!!
:lol:
Identifying narcissists isn't difficult. Just look for the person who is constantly fishing for compliments
and admiration while breaking down over even the slightest bit of criticism.

We have the freedom to choose our actions, but we do not get to choose our consequences.
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kenny
HOLY CARP!!!
So do I have stem cells?
... or did they have to be harvested from my umbilical cord back when I was born?

If I gots some now how do they harvest them?
Where are they?
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Improviso
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HOLY CARP!!!
kenny
Feb 14 2012, 06:12 PM
If I gots some now how do they harvest them?
Where are they?
Posted Image Let's take a look.

:D
Identifying narcissists isn't difficult. Just look for the person who is constantly fishing for compliments
and admiration while breaking down over even the slightest bit of criticism.

We have the freedom to choose our actions, but we do not get to choose our consequences.
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George K
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Finally
kenny
Feb 14 2012, 06:12 PM
So do I have stem cells?
Yep. We all do.
Quote:
 
If I gots some now how do they harvest them?

http://en.wikipedia.org/wiki/Stem_cell
Quote:
 
Stem cells are biological cells found in all multicellular organisms, that can divide (through mitosis) and differentiate into diverse specialized cell types and can self-renew to produce more stem cells. In mammals, there are two broad types of stem cells: embryonic stem cells, which are isolated from the inner cell mass of blastocysts, and adult stem cells, which are found in various tissues. In adult organisms, stem cells and progenitor cells act as a repair system for the body, replenishing adult tissues. In a developing embryo, stem cells can differentiate into all the specialized cells (these are called pluripotent cells), but also maintain the normal turnover of regenerative organs, such as blood, skin, or intestinal tissues.

There are three sources of autologous adult stem cells: 1) Bone marrow, which requires extraction by harvesting, that is, drilling into bone (typically the femur or iliac crest), 2) Adipose tissue (lipid cells), which requires extraction by liposuction, and 3) Blood, which requires extraction through pheresis, wherein blood is drawn from the donor (similar to a blood donation), passed through a machine that extracts the stem cells and returns other portions of the blood to the donor. Stem cells can also be taken from umbilical cord blood. Of all stem cell types, autologous harvesting involves the least risk. By definition, autologous cells are obtained from one's own body, just as one may bank his or her own blood for elective surgical procedures.

Highly plastic adult stem cells are routinely used in medical therapies, for example bone marrow transplantation. Stem cells can now be artificially grown and transformed (differentiated) into specialized cell types with characteristics consistent with cells of various tissues such as muscles or nerves through cell culture. Embryonic cell lines and autologous embryonic stem cells generated through therapeutic cloning have also been proposed as promising candidates for future therapies.
A guide to GKSR: Click

"Now look here, you Baltic gas passer... "
- Mik, 6/14/08


Nothing is as effective as homeopathy.

I'd rather listen to an hour of Abba than an hour of The Beatles.
- Klaus, 4/29/18
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kenny
HOLY CARP!!!
Thanks George.

Improv . . . :tsktsk: :lol2:
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Copper
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Shortstop
George K
Feb 14 2012, 03:28 PM
Faster, please....

So all those broken hearts get fixed - nice St. Valentine's Day story.

And we won't need as much Medicare money now - budget problems solved.
The Confederate soldier was peculiar in that he was ever ready to fight, but never ready to submit to the routine duty and discipline of the camp or the march. The soldiers were determined to be soldiers after their own notions, and do their duty, for the love of it, as they thought best. Carlton McCarthy
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Friday
Senior Carp
Suzanne Somers claimed to use stem cells to regrow her boobs.
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Dewey
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HOLY CARP!!!
jon-nyc
Feb 14 2012, 05:43 PM
Faster, indeed. Then lets regrow lung tissue the same way.
:uparrow: +1.
"By nature, i prefer brevity." - John Calvin, Institutes of the Christian Religion, p. 685.

"Never waste your time trying to explain yourself to people who are committed to misunderstanding you." - Anonymous

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KlavierBauer
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HOLY CARP!!!
Quote:
 
Faster, indeed. Then lets regrow lung tissue the same way.

Bingo buddy.
For my entire adult life I've been waiting to hear that a kidney can be fully repaired/regenerated with stem cells.
Two years ago I added lungs to the list.

Let's do this...
"I realize you want him to touch you all over and give you babies, but his handling of the PR side really did screw the pooch." - Ivory Thumper
"He said sleepily: "Don't worry mom, my dick is like hot logs in the morning." - Apple

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KlavierBauer
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HOLY CARP!!!
Kenny:
Much of stem cell research these days is done with patient's own stem cells - many scientists preferring these to embryonic stem cells.
And as GK said, existing embryonic stem cell lines are OK.
Like the embryonic cells used to make vaccines, these lines have been alive and flourishing for nearly 40 years in some cases - so using them doesn't involve creating/destroying embryos.
Much of the embryonic stem cell debacle stems from ignorance and people's propensity to get emotionally involved with issues that involve words they've been programmed to be sensitive to (like "embryo").
"I realize you want him to touch you all over and give you babies, but his handling of the PR side really did screw the pooch." - Ivory Thumper
"He said sleepily: "Don't worry mom, my dick is like hot logs in the morning." - Apple

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