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Cancer Cured? By the British?; Jolly Would Owe Someone an Apology
Topic Started: Jun 20 2005, 03:59 AM (1,246 Views)
QuirtEvans
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I Owe It All To John D'Oh
Trial of cancer drug shows promise for breast, prostate, bowel, kidney, skin and ovarian cancers
17 Jun 2005

Promising results from the UK's first clinical trial of a prototype cancer drug have raised the prospect of an effective new treatment against a range of cancers, including breast, prostate, bowel, kidney, ovarian and skin cancer.

Published today* (Thursday) the research reveals the drug's ability to attack cancer cells on a number of fronts at the same time, and gives the first indication that it may have the potential to halt the disease in patients.

The Cancer Research UK funded trial was carried out by Institute of Cancer Research scientists at The Royal Marsden Hospital. The drug was provided by the National Cancer Institute in the US under a Cooperative Research and Development Agreement with the US biotech company, Kosan Biosciences Inc.

The research team already knew that the drug - labelled 17AAG - selectively and potently blocks the growth of a wide range of common cancer cells in the laboratory, causing them to 'commit suicide'.

This new study confirmed that it also works biochemically as intended in patients with a variety of cancer types. Clinical results in two patients with malignant melanoma provide early evidence that the drug may be able to tackle cancers that are resistant to other drugs.

Further trials, each looking at patients with a specific tumour type, are planned to establish the extent of the drug's treatment potential in different kinds of cancer.

The Cancer Research UK funded team is already testing the drug in patients with malignant melanoma, and other teams in the US are looking at patients with prostate, breast and kidney cancer.

The drug works by targeting and inactivating a crucial molecule called Hsp90. Hsp90 plays an important role in the transmission of messages around the cell by helping to control the structure and function of a large number of other molecules many of which are critical for cancer growth.

Cancer cells are dependent upon these molecules and will die if deprived of them, whereas healthy cells are not seriously affected by their loss. This makes the new drug highly targeted, as well as deadly, to cancer cells. The drug simultaneously targets many molecules vital for growth, including proteins, BCR-ABL, c-RAF-1, AKT/PKB, CDK4 and mutant P53. Using this multi-pronged attack, the drug acts like several different treatments combined, reducing the chances that a tumour will develop resistance.

Different doses of the drug were given to 30 patients with a range of common cancers. To find out whether the drug hit its target, the team measured the levels of two of the molecules vital for cancer growth - c-RAF-1 and CDK4 - and found that they consistently fell in response to the drug. By careful monitoring of the patients' progress over time, the team was able to determine the optimum dose for the drug to act.

Lead researcher, Professor Paul Workman of the Cancer Research UK Centre for Cancer Therapeutics at The Institute of Cancer Research, says: "Hsp90 helps to maintain the shape, stability and function of all sorts of important molecules, a large number of which play critical roles in the development of cancer. The results of this research suggest that, by blocking the action of Hsp90, the drug has the potential to attack cancer by shutting down a range of systems that cancer cells use to grow and spread."

Professor John Toy, Cancer Research UK's Medical Director, says: "These results, are very early and, although encouraging, much more work to assess the drug's effect in large numbers of patients still needs to be done.

"However, what's particularly exciting about this drug is that it targets so many different features of cancer's machinery all at once, which should make it much more difficult for tumours to develop resistance to treatment."

Professor Peter Rigby, Chief Executive of The Institute of Cancer Research, says: "This early trial indicates the potential of this drug for future cancer treatment. Although further trials need to be conducted, early indications suggest that the multi-pronged attack by this drug shows promise in treating a range of cancers."

*Journal of Clinical Oncology.
A phase I pharmacokinetic (PK) and pharmacodynamic (PD) study of 17-allylamino, 17-demethoxygeldanamycin (17- AAG) in patients with advanced malignancies" Udai Banerji, Anne O'Donnell, Michelle Scurr, Simon Pacey, Sarah Stapleton, Yasmin Asad, Laura Simmons, Alison Maloney, Florence Raynaud, Maeli Campbell, Michael Walton, Sunil Lakhani, Stanley Kaye, Paul Workman, and Ian Judson.

The trial

The drug (17AAG) was administered intravenously once a week without a break. Patients with the following types of cancer took part in the trial: melanoma, sarcoma, breast, colon, mesothelioma (cancer of the mesothelial cells that cover the outer surface of most internal organs of the body), ovarian, renal, non-small cell lung cancer, pancreatic, primary peritoneal (cancer of the peritoneum - the membrane that forms the lining of the abdominal cavity), parotid (cancer of the salivary glands), and unknown primary (cancer that has started in an unknown part of the body).

For more information about different types of cancer, diagnosis and treatment for patients and their families, visit Cancer Research UK's patient information website CancerHelp UK.

Hsp90

Hsp90 is a chaperone protein and has the job of ensuring that molecules within the cell are folded into the correct shape. Protein molecules are made up of long strips of amino acids, carefully folded into particular three-dimensional structures.

Incorrect folding will stop a molecule from working and may lead to its breakdown by the cell's mechanisms that are constantly on the lookout for molecules that are damaged or defunct.

When inactivated, Hsp90 can no longer keep other molecules within the cell in their correct shape, causing some to lose their activity and others to be broken down or removed.

Cancer Research UK

-- Cancer Research UK's vision is to conquer cancer through world-class research.

-- The charity works alone and in partnership with others to carry out research into the biology and causes of cancer, to develop effective treatments, improve the quality of life for cancer patients, reduce the number of people getting cancer and to provide authoritative information on cancer. Cancer Research UK is the world's leading independent charity dedicated to research on the causes, treatment and prevention of cancer.

-- For further information about Cancer Research UK's work or to find out how to support the charity, please call 020 7009 8820.

-- For further information about Reduce the Risk please visit http://www.reducetherisk.org.uk.

The Institute of Cancer Research and The Royal Marsden Hospital

-- The Institute of Cancer Research works in a unique partnership with the Royal Marsden Hospital, forming the largest comprehensive cancer centre in Europe, with more than 40,000 patients being seen at the hospital's sites in Chelsea and Sutton each year. This relationship enables us to stay in close daily contact with those on the frontline in the fight against cancer - the clinicians, the carers and most importantly, the patients

-- The Institute of Cancer Research is Europe's leading cancer research centre with expert scientists working on cutting edge research. It was founded in 1909 to carry out research into the causes of cancer and to develop new strategies for its prevention, diagnosis, treatment and care. The Institute is unrivalled in its record of cancer drug discovery and development

The link is here: http://www.medicalnewstoday.com/medicalnews.php?newsid=26324
It would be unwise to underestimate what large groups of ill-informed people acting together can achieve. -- John D'Oh, January 14, 2010.
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kenny
HOLY CARP!!!
Clue me in.
What does this have to do with Jolly?

Sorry, I don't have time to read every single post here.
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QuirtEvans
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I Owe It All To John D'Oh
In another thread, in a debate with Lucy about whether inpatient chemotherapy is highly unusual or not, Jolly made a couple of disparaging remarks about the quality of British medical practices.

It would be unwise to underestimate what large groups of ill-informed people acting together can achieve. -- John D'Oh, January 14, 2010.
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Wacki Iraqi
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Senior Carp
Hold on Quirt, we've already been through this and deduced that Jolly knows very little about the range of medical practices, he himself stated that he was not an MD and that he dealt mostly with the hiring and firing of cleaning staff. Even with Larry wheeling him through wards, we all know that the drip was running through too quick and that death was inevitable, may they rest in peas.
You're an atheist when considering Zeus, Apollo, Amon Ra, Mithras, Baal, Thor, Wotan, the Golden Calf and the Flying Spaghetti Monster.........I just go one God further.
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kentcouncil
Fulla-Carp
QuirtEvans
Jun 20 2005, 07:32 AM
In another thread, in a debate with Lucy about whether inpatient chemotherapy is highly unusual or not, Jolly made a couple of disparaging remarks about the quality of British medical practices.

Medical practice and medical research are two separate things.
It was a confusion of ideas between him and one of the lions he was hunting in Kenya that had caused A. B. Spottsworth to make the obituary column. He thought the lion was dead, and the lion thought it wasn't.

- P.G. Wodehouse
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Wacki Iraqi
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kentcouncil
Jun 20 2005, 05:01 AM
QuirtEvans
Jun 20 2005, 07:32 AM
In another thread, in a debate with Lucy about whether inpatient chemotherapy is highly unusual or not, Jolly made a couple of disparaging remarks about the quality of British medical practices.

Medical practice and medical research are two separate things.

Yeah, but it's pretty difficult to do any of the former without first doing a bit of the latter. Sail on. :pirate:
You're an atheist when considering Zeus, Apollo, Amon Ra, Mithras, Baal, Thor, Wotan, the Golden Calf and the Flying Spaghetti Monster.........I just go one God further.
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Jolly
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Geaux Tigers!
Wacki Iraqi
Jun 20 2005, 04:47 AM
Hold on Quirt, we've already been through this and deduced that Jolly knows very little about the range of medical practices, he himself stated that he was not an MD and that he dealt mostly with the hiring and firing of cleaning staff. Even with Larry wheeling him through wards, we all know that the drip was running through too quick and that death was inevitable, may they rest in peas.

I don't think I disparaged the knowledge base of British medicine.

I do think that they are technologically backwards in everday medical technology.

Since y'all have suddenly become experts, please tell me what British firms can compete in the deliverance of medical technology with Toshiba, GE, Beckman-Coulter, Bayer, Roche, American Dade, Hitachi, or Bio Mereaux?
The main obstacle to a stable and just world order is the United States.- George Soros
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Wacki Iraqi
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Jolly
Jun 20 2005, 05:57 AM
Wacki Iraqi
Jun 20 2005, 04:47 AM
Hold on Quirt, we've already been through this and deduced that Jolly knows very little about the range of medical practices, he himself stated that he was not an MD and that he dealt mostly with the hiring and firing of cleaning staff. Even with Larry wheeling him through wards, we all know that the drip was running through too quick and that death was inevitable, may they rest in peas.

I don't think I disparaged the knowledge base of British medicine.

I do think that they are technologically backwards in everday medical technology.

Since y'all have suddenly become experts, please tell me what British firms can compete in the deliverance of medical technology with Toshiba, GE, Beckman-Coulter, Bayer, Roche, American Dade, Hitachi, or Bio Mereaux?

We've come a long way
said the Cigarette Scientist
as he destroyed a live rabbit
to show the students how it worked

He took its heart out
plugged ut unto an electric pump
that kept it beating for nearly two hours

I know rabbits who can keep their hearts
beating for nearly seven years

And look at the electricity they save

Spike Milligan.
You're an atheist when considering Zeus, Apollo, Amon Ra, Mithras, Baal, Thor, Wotan, the Golden Calf and the Flying Spaghetti Monster.........I just go one God further.
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Larry
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Mmmmmmm, pie!
Funny, Lucy stomps off in a snit, and now Wacky is back, apparently looking for every opportunity to take a swipe Jolly or me. Lay off guy - I'm not in the mood, and it *will* get ugly.

Of the Pokatwat Tribe

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Wacki Iraqi
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Larry
Jun 20 2005, 06:04 AM
Funny, Lucy stomps off in a snit, and now Wacky is back, apparently looking for every opportunity to take a swipe Jolly or me. Lay off guy - I'm not in the mood, and it *will* get ugly.

Oh really, like you think you scare me. You can't intimidate me so stick to trying it with the girls Larry. We wouldn't be having this sort of conversation if you had any manners. So try to ignore me and we'll get on just dandy bub. :smokin:
You're an atheist when considering Zeus, Apollo, Amon Ra, Mithras, Baal, Thor, Wotan, the Golden Calf and the Flying Spaghetti Monster.........I just go one God further.
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Jolly
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Geaux Tigers!
Wacki Iraqi
Jun 20 2005, 06:02 AM
Jolly
Jun 20 2005, 05:57 AM
Wacki Iraqi
Jun 20 2005, 04:47 AM
Hold on Quirt, we've already been through this and deduced that Jolly knows very little about the range of medical practices, he himself stated that he was not an MD and that he dealt mostly with the hiring and firing of cleaning staff. Even with Larry wheeling him through wards, we all know that the drip was running through too quick and that death was inevitable, may they rest in peas.

I don't think I disparaged the knowledge base of British medicine.

I do think that they are technologically backwards in everday medical technology.

Since y'all have suddenly become experts, please tell me what British firms can compete in the deliverance of medical technology with Toshiba, GE, Beckman-Coulter, Bayer, Roche, American Dade, Hitachi, or Bio Mereaux?

We've come a long way
said the Cigarette Scientist
as he destroyed a live rabbit
to show the students how it worked

He took its heart out
plugged ut unto an electric pump
that kept it beating for nearly two hours

I know rabbits who can keep their hearts
beating for nearly seven years

And look at the electricity they save

Spike Milligan.

Listen up, buddy-rough.

I asked you a question, a very simple question, framed with companies whose technology I know from first-hand experience.

If you knoweth of what you speak, and you've been the places you say you've been, I know the hours have not passed so swiftly that you didn't peruse the names on the peri-pumps, or the makers of the IV bags.

So tell me those British companies that are delivering everyday medical care in the hospitals throughout your country. Personally, I don't know of any over here, but perhaps things are different back in England.
The main obstacle to a stable and just world order is the United States.- George Soros
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Larry
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Mmmmmmm, pie!
That's easy to say when there's an ocean between us isn't it? Aw....... lucy wucy got her feelings hurt, so the big bad Wacky tacky is gonna play the tough guy and come to her defense..... how sweet.....

I'll be happy to ignore you, asshole, just as soon as you stop taking stupid little swipes at me in every post you write.
Of the Pokatwat Tribe

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Jolly
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Geaux Tigers!
Wacki Iraqi
Jun 20 2005, 06:10 AM
Larry
Jun 20 2005, 06:04 AM
Funny, Lucy stomps off in a snit, and now Wacky is back, apparently looking for every opportunity to take a swipe Jolly or me.  Lay off guy - I'm not in the mood, and it *will* get ugly.

Oh really, like you think you scare me. You can't intimidate me so stick to trying it with the girls Larry. We wouldn't be having this sort of conversation if you had any manners. So try to ignore me and we'll get on just dandy bub. :smokin:

Bub,

There isn't going to be any ignoring happening, not when youhave decided to walk in swinging a dead cat.

Think about your current boorish behavior, and meditate upon it.

You want to act nice, folks can be nice.

You want to be an ass, don't be surprised if others can give as good as they get.
The main obstacle to a stable and just world order is the United States.- George Soros
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Wacki Iraqi
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Larry
Jun 20 2005, 06:14 AM
That's easy to say when there's an ocean between us isn't it? Aw....... lucy wucy got her feelings hurt, so the big bad Wacky tacky is gonna play the tough guy..... how sweet.....

You really don't know Lucy much do you? More importantly you know even less about me. Walk on.
You're an atheist when considering Zeus, Apollo, Amon Ra, Mithras, Baal, Thor, Wotan, the Golden Calf and the Flying Spaghetti Monster.........I just go one God further.
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Larry
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Mmmmmmm, pie!
Oooooooooh, I'm scared NOW!...... Yeah!!!!

You don't know me either. So lay off.
Of the Pokatwat Tribe

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Wacki Iraqi
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Larry
Jun 20 2005, 06:22 AM
Oooooooooh, I'm scared NOW!...... Yeah!!!!

You don't know me either. So lay off.

Lay where i'm 2,000 miles away. Grow up, i'd hate to have to come to a coffee room party and ignore you all evening.
You're an atheist when considering Zeus, Apollo, Amon Ra, Mithras, Baal, Thor, Wotan, the Golden Calf and the Flying Spaghetti Monster.........I just go one God further.
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Luke's Dad
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Emperor Pengin
As I said elsewhere. Cool it guys.

Wacki, I'm sorry if these guys got a little carried away in the way they treated Lucy. She is well liked and respected on this forum. That being said, she also attacked unjustly a member of this forum who has proven himself to be a good person, and quite knowledgeable. His advice has helped me and others in the past. He is well liked and respected. This is not somebody that should be treated disparagingly. Drop it and let it go.

The same goes for Jolly and the others. This isn't a battle worth fighting.
The problem with having an open mind is that people keep trying to put things in it.
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Larry
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Mmmmmmm, pie!
Oh, you wouldn't ignore me very long. About the second time you said something like what you've written in this thread, I'd give you a whole new reason to see the inside of a hospital.

You started this pal, not me.
Of the Pokatwat Tribe

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Wacki Iraqi
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Luke's Dad
Jun 20 2005, 06:28 AM
As I said elsewhere. Cool it guys.

Wacki, I'm sorry if these guys got a little carried away in the way they treated Lucy. She is well liked and respected on this forum. That being said, she also attacked unjustly a member of this forum who has proven himself to be a good person, and quite knowledgeable. His advice has helped me and others in the past. He is well liked and respected. This is not somebody that should be treated disparagingly. Drop it and let it go.

The same goes for Jolly and the others. This isn't a battle worth fighting.

Lucy fights her own battles Lukey but has'nt attacked anyone seeing as theres a big space between all concerned. These "honest" people you speak of have continually been nasty and have bullied their way through differences and have not understood the damage they have tried to do to others. I accept they may be friends to you and this argument by no means reflects on you, no matter the rights or wrongs. So be of good cheer and post in a manner that suits your condition. :wink:
You're an atheist when considering Zeus, Apollo, Amon Ra, Mithras, Baal, Thor, Wotan, the Golden Calf and the Flying Spaghetti Monster.........I just go one God further.
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Wacki Iraqi
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Larry
Jun 20 2005, 06:30 AM
Oh, you wouldn't ignore me very long. About the second time you said something like what you've written in this thread, I'd give you a whole new reason to see the inside of a hospital.

You started this pal, not me.

Sorry i don't understand what you are saying, aren't we arguing in writing about a disagreement? Or is there something else to you.
You're an atheist when considering Zeus, Apollo, Amon Ra, Mithras, Baal, Thor, Wotan, the Golden Calf and the Flying Spaghetti Monster.........I just go one God further.
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Jolly
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Geaux Tigers!
Wacki Iraqi
Jun 20 2005, 06:36 AM
Luke's Dad
Jun 20 2005, 06:28 AM
As I said elsewhere. Cool it guys.

Wacki, I'm sorry if these guys got a little carried away in the way they treated Lucy. She is well liked and respected on this forum. That being said, she also attacked unjustly a member of this forum who has proven himself to be a good person, and quite knowledgeable. His advice has helped me and others in the past. He is well liked and respected. This is not somebody that should be treated disparagingly. Drop it and let it go.

The same goes for Jolly and the others. This isn't a battle worth fighting.

Lucy fights her own battles Lukey but has'nt attacked anyone seeing as theres a big space between all concerned. These "honest" people you speak of have continually been nasty and have bullied their way through differences and have not understood the damage they have tried to do to others. I accept they may be friends to you and this argument by no means reflects on you, no matter the rights or wrongs. So be of good cheer and post in a manner that suits your condition. :wink:

No sir, apparently this is a tag-team effort.

Besides, I don't see where Lucy was "bullied" into anything, or maybe I've missed something...she and I have a disagreement on the treatment of oncology patients. I am speaking from my perspective, and have said so.

Now, if someone with bonafides can refute my general statements about those things, please do so. But I don't think that Lucy lives under a different set of rules than the rest of us around here.
The main obstacle to a stable and just world order is the United States.- George Soros
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justme
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HOLY CARP!!!
I missed something somewhere. Oh well.... I was going to look for what I missed but if all I've missed has been meanspirited bullying I think I'll pass.

Some of us get tired of all the meanspirited nastiness.

You meanspirited people have already chased several good people away. Not because they weren't strong and couldn't fight but because they simply grew bored with you.

It's BORING and embarassing. It also only makes the bullies look bad.

Oh, forget it. :rolleyes2:
"Men sway more towards hussies." G-D3
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Larry
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Mmmmmmm, pie!
For what it's worth to you Peggy, I didn't start this, and neither did Jolly. But I'm finished with it.
Of the Pokatwat Tribe

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justme
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HOLY CARP!!!
Larry
Jun 20 2005, 10:45 AM
For what it's worth to you Peggy, I didn't start this, and neither did Jolly. But I'm finished with it.

Larry, I don't know who started what. But, I'm glad you're finished with it. When one wakes up in the morning and all they read is this crap one's day isn't starting so well.

"Men sway more towards hussies." G-D3
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Wacki Iraqi
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Senior Carp
Jolly
Jun 20 2005, 06:43 AM
Wacki Iraqi
Jun 20 2005, 06:36 AM
Luke's Dad
Jun 20 2005, 06:28 AM
As I said elsewhere. Cool it guys.

Wacki, I'm sorry if these guys got a little carried away in the way they treated Lucy. She is well liked and respected on this forum. That being said, she also attacked unjustly a member of this forum who has proven himself to be a good person, and quite knowledgeable. His advice has helped me and others in the past. He is well liked and respected. This is not somebody that should be treated disparagingly. Drop it and let it go.

The same goes for Jolly and the others. This isn't a battle worth fighting.

Lucy fights her own battles Lukey but has'nt attacked anyone seeing as theres a big space between all concerned. These "honest" people you speak of have continually been nasty and have bullied their way through differences and have not understood the damage they have tried to do to others. I accept they may be friends to you and this argument by no means reflects on you, no matter the rights or wrongs. So be of good cheer and post in a manner that suits your condition. :wink:

No sir, apparently this is a tag-team effort.

Besides, I don't see where Lucy was "bullied" into anything, or maybe I've missed something...she and I have a disagreement on the treatment of oncology patients. I am speaking from my perspective, and have said so.

Now, if someone with bonafides can refute my general statements about those things, please do so. But I don't think that Lucy lives under a different set of rules than the rest of us around here.

Jolly please stop pretending that you are only concerned with the issues of cancer treatment, your'e looking like a fool. Everyone knows that you just wanted to bully and get a one up on Lucy because her boyfriend had cancer. You then tried to hurt me in the same way because you hate the fact that someone could be popular or liked for any reason. YOU JUST WANTED TO HURT PEOPLE stop pretending, because you keep giving your true feelings away and everyone can see you.
You're an atheist when considering Zeus, Apollo, Amon Ra, Mithras, Baal, Thor, Wotan, the Golden Calf and the Flying Spaghetti Monster.........I just go one God further.
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